Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(3-Nitro-phenyl)-acrylonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 3-Nitrobenzaldehyde | HCID 7449 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Diethyl (cyanomethyl)phosphonate | HCID 75676 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(3-Nitro-phenyl)-acrylonitrile | HCID 55669 | — |
반응 단계
At 0° C., 75.5 g of diethyl cyanomethylphosphonate dissolved in tetrahydrofuran are poured into a suspension of sodium hydride in tetrahydrofuran. After 30 minutes' contact at ambient temperature, 56 g of 3-nitrobenzaldehyde dissolved in tetrahydrofuran are poured in. After 1 hour, hydrolysis is carried out with 300 ml of water and then the solvent is concentrated. Following extraction with dichloromethane, washing the organic phase with water, drying over magnesium sulphate and concentration, the precipitate is taken up in diethyl ether and filtered off.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06784183B2 |
| 출처 데이터셋 | uspto-grants-2004_08 |
| ORD ID | ord-83ff63ba8c864af485b35e9f901d6e97 |
| 출처 메모 | uspto-grants-2004_08 |