反应详情

At 0° C., 75.5 g of diethyl cyanomethylphosphonate dissolved in tetrahydrofuran are poured into a suspension of sodium hydride in tetrahydrofuran. After 30 minutes' contact at ambient temperature, 56 g of 3-nitrobenzaldehyde dissolved in tetrahydrofuran are poured in. After 1 hour, hydrolysis is carried out with 300 ml of water and then the solvent is concentrated. Following extraction with dichloromethane, washing the organic phase with water, drying over magnesium sulphate and concentration, the precipitate is taken up in diethyl ether and filtered off.

1. additionare poured in
2. waitAfter 1 hour
3. customhydrolysis
4. concentrationthe solvent is concentrated
5. extractionextraction with dichloromethane
6. washwashing the organic phase with water
7. dry with materialdrying over magnesium sulphate and concentration
8. filtrationfiltered off