Imidazole → 1,4-Dichloro-2-(5-iodopent-1-ynyl)benzene

HRID 1837531

반응식

HRID 1837531 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]#[C:10][CH2:11][CH2:12][CH2:13]O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N1C=CN=C1.[I:39]I>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]#[C:10][CH2:11][CH2:12][CH2:13][I:39]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 807IodineHCID 11776TriphenylphosphineHCID 223207595-(2,5-Dichlorophenyl)pent-4-yn-1-ol

생성물 1

HCID 129889421,4-Dichloro-2-(5-iodopent-1-ynyl)benzene수율 72.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

5-(2,5-Dichlorophenyl)pent-4-yn-1-ol (13.7 g, 59.8 mmol), triphenylphosphine (20.4 g, 77.8 mmol), and imidazole (5.71 g, 83.8 mmol) in a mixed solvent (100 ml acetonitrile-150 ml ether) was stirred under nitrogen at 0° C., and to this was slowly added iodine (21.3 g, 83.8 mmol). The solution was allowed to warm to room temperature and stirring was continued for 18 hours. This was chromatographed on silica gel with hexane to give the title compound (14.7 g,72%), MS m/z 337.9 (M−H calcd. for C11H9Cl2I=338.0).

후처리

  1. customThis was chromatographed on silica gel with hexane

출처 및 근거

ORD 기록
ord-f323ca28428c4bb2907b98a8f7517818
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784184B2

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