Tetrahydrofuran → 2-(2-Methoxy-3-pyridinyl)ethanol

HRID 1837704노트

반응식

HRID 1837704 반응식
[CH3:1][O:2][C:3]1[C:8]([CH2:9][C:10](O)=[O:11])=[CH:7][CH:6]=[CH:5][N:4]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C1COCC1.[OH-].[Na+]>O>[CH3:1][O:2][C:3]1[C:8]([CH2:9][CH2:10][OH:11])=[CH:7][CH:6]=[CH:5][N:4]=1

참가 물질

6

반응물 4

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 226783192-Methoxy-3-pyridineacetic acid

생성물 1

HCID 140623082-(2-Methoxy-3-pyridinyl)ethanol수율 54.6%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

2.4 g of (2-methoxy-3-pyridyl)acetic acid, 550 mg of lithium aluminum hydride and 20 ml of THF were stirred at room temperature for 0.5 hour. 0.27 ml of water, 3.9 ml of a 3.8N aqueous sodium hydroxide and 0.78 ml of water were successively added thereto, and the resulting solid was filtered off. The filtrate was evaporated, and the residue was purified by silica gel chromatography (hexane:ethyl acetate=2:1, subsequently 1:1), to give 1.2 g of a yellow oil.

후처리

  1. filtrationthe resulting solid was filtered off
  2. customThe filtrate was evaporated
  3. customthe residue was purified by silica gel chromatography (hexane

출처 및 근거

ORD 기록
ord-1f5f935e8a8a4cf991801daa2511d6f5
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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