Trimethyl orthoformate → HCID 22678608, 화합물

HRID 1837710노트

반응식

HRID 1837710 반응식
[Br:1][C:2]1[CH:3]=[C:4](C=O)[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH:12]([O:17][CH3:18])([O:15][CH3:16])OC.O.[O-2].[O-2].[O-2].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.[Al+3].[Al+3]>ClCCl>[CH3:18][O:17][CH:12]([O:15][CH3:16])[C:4]1[C:5]([O:8][CH3:9])=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=1

참가 물질

5

반응물 3

HCID 9005Trimethyl orthoformateHCID 15164035-Bromo-2-methoxypyridine-3-carbaldehydeHCID 71586775Bentonite

생성물 1

HCID 22678608HCID 22678608, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2.58 g of 5-bromo-2-methoxy-3-pyridinecarboxaldehyde was dissolved in 30 ml of dichloromethane, a mixture of 9 ml of trimethyl orthoformate and montmorillonite K-10 (3 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. After filtering the reaction solution, the filtrate was evaporated. To the residue was added ethyl acetate, followed by filtering through alumina. The filtrate was evaporated, to give 3.09 g of the title compound as a yellow oil.

후처리

  1. additionwas added
  2. filtrationAfter filtering the reaction solution
  3. customthe filtrate was evaporated
  4. additionTo the residue was added ethyl acetate
  5. filtrationby filtering through alumina
  6. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-c6c9ebe904244d8a947ff498a75c7d9b
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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