Hydrochloric Acid → HCID 22678413, 화합물

HRID 1837712노트

반응식

HRID 1837712 반응식
C[O:2][CH:3](OC)[C:4]1[C:5]([O:14][CH3:15])=[N:6][CH:7]=[C:8]([S:10]([CH3:13])(=[O:12])=[O:11])[CH:9]=1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH3:13][S:10]([C:8]1[CH:9]=[C:4]([CH:3]=[O:2])[C:5]([O:14][CH3:15])=[N:6][CH:7]=1)(=[O:12])=[O:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 22678645HCID 22678645, 화합물

생성물 1

HCID 22678413HCID 22678413, 화합물수율 92.9%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

0.81 g of 5-(methylsulfonyl)-2-methoxy-3-pyridinecarboxaldehyde dimethyl acetal was dissolved in 8 ml of acetone, 2 ml of 5N-hydrochloric acid was added thereto, and the mixture was stirred at room temperature for 30 minutes. An aqueous sodium carbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, n-hexane was added to the residue and the resulting product was collected by filtration, to give 0.62 g of the title compound as a white powder.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated
  5. additionn-hexane was added to the residue
  6. filtrationthe resulting product was collected by filtration

출처 및 근거

ORD 기록
ord-00123e3a36254d27ad27ebb74abdefbf
출처 데이터셋
uspto-grants-2004_08
특허 번호
US06784192B2

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