Water → 1,2-Dimethylbenzimidazole
반응식
[CH3:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[OH-].[K+].[CH3:13]I.O>CC(C)=O>[CH3:13][N:3]1[C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=[C:2]1[CH3:1]참가 물질
6
실험 절차
To 10 grams of 2-methyl benzimidazole (75 mM), crushed 25 grams of crushed KOH (450 mM) in 300 ml acetone, methyl iodide (15 grams, 105 mM) was added at a continuous drip for 0.5 hours, at room temperature. Following additional 0.5 hour, water was added, the reaction extracted with dichloromethane, evaporated and chromatographed on silica gel to yield 6 grams (54%) of 1,2-dimethyl benzimidazole as a white solid having a melting point of 102° C.
후처리
- additionwas added at a continuous drip for 0.5 hours, at room temperature
- extractionthe reaction extracted with dichloromethane
- customevaporated
- customchromatographed on silica gel
출처 및 근거
- ORD 기록
- ord-5af9febec7e94364881866688e658cea
- 출처 데이터셋
- uspto-grants-2004_01
- 특허 번호
- US06673798B2
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