Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glycosmicine → (+/-)-N-Methyl-2-[2-(1-methylquinazolin-2,4-dione-3-yl]ethyl)-N-(4-phenoxybenzenesulfonyl)glycine Allyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glycosmicine | HCID 11788 | — |
| 반응물 | (+/-)-N-(tert-butoxycarbonyl)homoserine allyl ester | HCID 12042107 | — |
| 반응물 | (+/-)-2-(2-hydroxyethyl)-N-methyl-N-(4-phenoxybenzenesulfonyl)glycine allyl ester | HCID 18753502 | — |
| 생성물 | Phthalimide | HCID 6809 | — |
| 생성물 | (+/-)-N-Methyl-2-[2-(1-methylquinazolin-2,4-dione-3-yl]ethyl)-N-(4-phenoxybenzenesulfonyl)glycine Allyl Ester | HCID 17801562 | 72% |
반응 단계
In a similar manner to that described in Example 1(1), a reaction was carried out using (±)-2-(2-hydroxyethyl)-N-methyl-N-(4-phenoxybenzenesulfonyl)glycine allyl ester, the product of Example 41(2), instead of (±)-N-(tert-butoxycarbonyl)homoserine allyl ester, and using 1-methylquinazoline-2,4-dione, instead of phthalimide, to afford the desired compound (yield 72%) as a white powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06673804B1 |
| 출처 데이터셋 | uspto-grants-2004_01 |
| ORD ID | ord-aa14fb575da14ca08bfc7168fe232b3e |
| 출처 메모 | uspto-grants-2004_01 |