HRID1838424

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11788

Glycosmicine

C9H8N2O2

HCID12042107

未命名化合物

结构：C=CCOC(=O)C(CCO)N(C)S(=O)(=O)c1ccc(Oc2ccccc2)cc1

HCID18753502

未命名化合物

PRODUCTS

生成物

HCID6809

Phthalimide

C8H5NO2

结构：C=CCOC(=O)C(CCn1c(=O)c2ccccc2n(C)c1=O)N(C)S(=O)(=O)c1ccc(Oc2ccccc2)cc1

HCID17801562

未命名化合物

收率 72%

PROCEDURE

实验过程

In a similar manner to that described in Example 1(1), a reaction was carried out using (±)-2-(2-hydroxyethyl)-N-methyl-N-(4-phenoxybenzenesulfonyl)glycine allyl ester, the product of Example 41(2), instead of (±)-N-(tert-butoxycarbonyl)homoserine allyl ester, and using 1-methylquinazoline-2,4-dione, instead of phthalimide, to afford the desired compound (yield 72%) as a white powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aa14fb575da14ca08bfc7168fe232b3e
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06673804B1
来源说明: uspto-grants-2004_01

反应 SMILES

[CH2:1]([O:4][C:5](=[O:28])[CH:6]([CH2:25][CH2:26]O)[N:7]([CH3:24])[S:8]([C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][CH:12]=1)(=[O:10])=[O:9])[CH:2]=[CH2:3].C(OC(=O)[C@H](CCO)NC(OC(C)(C)C)=O)C=C.[CH3:47][N:48]1[C:57]2[C:52](=[CH:53][CH:54]=[CH:55][CH:56]=2)[C:51](=[O:58])[NH:50][C:49]1=[O:59]>>[C:51]1(=[O:58])[NH:50][C:49](=[O:59])[C:57]2=[CH:56][CH:55]=[CH:54][CH:53]=[C:52]12.[CH2:1]([O:4][C:5](=[O:28])[CH:6]([CH2:25][CH2:26][N:50]1[C:51](=[O:58])[C:52]2[C:57](=[CH:56][CH:55]=[CH:54][CH:53]=2)[N:48]([CH3:47])[C:49]1=[O:59])[N:7]([CH3:24])[S:8]([C:11]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][CH:12]=1)(=[O:10])=[O:9])[CH:2]=[CH2:3]