Water → 7alpha-(5-Acetoxypentyl)-11beta-fluorooestr-4-ene-3,17-dione

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[F:1][C@H:2]1[CH2:19][C@@:17]2([CH3:18])[C@@H:13]([CH2:14][CH2:15][C:16]2=[O:20])[C@H:12]2[C@H:3]1[C@@H:4]1[C:9]([CH2:10][C@H:11]2[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][OH:26])=[CH:8][C:7](=[O:27])[CH2:6][CH2:5]1.[C:28](OC(=O)C)(=[O:30])[CH3:29].O>N1C=CC=CC=1>[C:28]([O:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][C@@H:11]1[CH2:10][C:9]2[C@H:4]([CH2:5][CH2:6][C:7](=[O:27])[CH:8]=2)[C@@H:3]2[C@@H:12]1[C@H:13]1[C@@:17]([CH2:19][C@@H:2]2[F:1])([CH3:18])[C:16](=[O:20])[CH2:15][CH2:14]1)(=[O:30])[CH3:29]

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실험 절차

20 g of 11β-fluoro-7α-(5-hydroxypentyl)oestr-4-ene-3,17-dione in 100 ml of pyridine are allowed to react at 25° C. for 2 h with 50 ml of acetic anhydride. 5 ml of water are then added at 0° C. and the mixture is stirred for 45 min. It is extracted with diethyl ether, washed with 2N sulphuric acid until free of pyridine and neutralized successively with saturated sodium hydrogencarbonate solution and water. After drying and concentrating in vacuo, the crude product is chromatographed on silica gel using a hexane-ethyl acetate gradient. 17 g of 7α-(5-acetoxypentyl)-11β-fluorooestr-4-ene-3,17-dione of melting point 78.4° C. are obtained.