Dansyl chloride → HCID 10346982, 화합물

HRID 1839078노트

반응식

HRID 1839078 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[C:17]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[N:10]=[C:9]([NH2:18])[C:8]=2[N:7]=[C:6]1[CH2:19][CH2:20][O:21][CH3:22].[CH3:23][N:24]([CH3:39])[C:25]1[CH:34]=[CH:33][CH:32]=[C:31]2[C:26]=1[CH:27]=[CH:28][CH:29]=[C:30]2[S:35](Cl)(=[O:37])=[O:36]>C(Cl)(Cl)Cl>[NH2:18][C:9]1[C:8]2[N:7]=[C:6]([CH2:19][CH2:20][O:21][CH3:22])[N:5]([CH2:4][CH2:3][CH2:2][NH:1][S:35]([C:30]3[C:31]4[C:26](=[C:25]([N:24]([CH3:39])[CH3:23])[CH:34]=[CH:33][CH:32]=4)[CH:27]=[CH:28][CH:29]=3)(=[O:37])=[O:36])[C:17]=2[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[N:10]=1

참가 물질

4

반응물 2

HCID 11801Dansyl chlorideHCID 223444281-(3-aminopropyl)-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine

생성물 1

HCID 10346982HCID 10346982, 화합물수율 53.3%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Using the general method of Example 245 except that chloroform was used as the solvent, 1-(3-aminopropyl)-2-(methoxyethyl)-1H-imidazo[4,5-c]quinolin-4-amine (1.53 g, 5.11 mmol) was reacted with 5-dimethylamino-1-naphthalenesulfonyl chloride (5.87 mmol) to provide 1.45 g of N-{3-[4-amino-2-(2-methoxyethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-5-(dimethylamino)naphthalene-1-sulfonamide as a yellow solid, m.p. 210-215° C. Analysis: Calculated for C28H32N6O3S.1.50 H2O: %C, 60.09; %N, 15.02; Found: %C, 59.89; %H, 6.22; %N, 14.86.

출처 및 근거

ORD 기록
ord-5b7603b700c24ea3824917e24eef5eb7
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06677349B1

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