Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

HRID 1840284노트

반응식

HRID 1840284 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 2735754HCID 2735754, 화합물

생성물 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

실험 절차

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature, the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p. >270° C. (ethanol).

후처리

  1. temperatureat reflux for 30 hours
  2. filtrationthe mixture was filtered by suction
  3. washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

출처 및 근거

ORD 기록
ord-7fe13fab2df94984b9a2a5dea6bc4f53
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06680319B2

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