Hydrochloric Acid → HCID 22631480, 화합물

HRID 1840434노트

반응식

HRID 1840434 반응식
[N:1]([CH2:4][CH2:5][CH2:6][S:7][C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12)=[N+]=[N-].Cl.[H][H]>C1COCC1.C(O)C.O.[Pd]>[NH2:1][CH2:4][CH2:5][CH2:6][S:7][C:8]1[N:9]=[CH:10][N:11]2[CH:15]=[CH:14][S:13][C:12]=12

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 22631922HCID 22631922, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 22631480HCID 22631480, 화합물

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 962Water용매HCID 21873804Tetrahydrofuran ethanol용매

실험 절차

7-(3-Azidopropyl)thioimidazo[5,1-b]thiazole (1.46 g) was dissolved in 30 ml of THF ethanol and 6 ml of water, and 6.1 ml of a 1 N aqueous hydrochloric acid solution and 1.46 g of 10% Pd-C were added to the solution. The air in the reaction vessel was replaced by hydrogen, and the contents of the reaction vessel were stirred at room temperature for 24 hr. The catalyst was removed by filtration on Celite, and was washed with water. The filtrate was concentrated under the reduced pressure. A 1 N aqueous sodium hydroxide solution (20 ml) was added to the residue, and the mixture was extracted with dichloromethane five times. The extract was dried over anhydrous magnesium sulfate. The solvent was removed by distillation to prepare 1.15 g of 7-(3-aminopropyl)thioimidazo[5,1-b]thiazole.

후처리

  1. customThe catalyst was removed by filtration on Celite
  2. washwas washed with water
  3. concentrationThe filtrate was concentrated under the reduced pressure
  4. additionA 1 N aqueous sodium hydroxide solution (20 ml) was added to the residue
  5. extractionthe mixture was extracted with dichloromethane five times
  6. dry with materialThe extract was dried over anhydrous magnesium sulfate
  7. customThe solvent was removed by distillation
  8. customto prepare 1.15 g of 7-(3-aminopropyl)thioimidazo[5,1-b]thiazole

출처 및 근거

ORD 기록
ord-7ab91ee2e1cd441e83bcba9f88e7a2c9
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06680313B2

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