Hydrochloric Acid → HCID 86590132, 화합물
반응식
CC(C)(OC([NH:7][C@H:8]([C:28]([N:30]1[CH2:35][CH2:34][CH:33]([CH2:36][CH3:37])[CH2:32][CH2:31]1)=[O:29])[CH2:9][CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[O:19])[CH2:14][CH2:13]1)=O)C.[ClH:39]>ClCCl>[ClH:39].[NH2:7][C@H:8]([C:28]([N:30]1[CH2:35][CH2:34][CH:33]([CH2:36][CH3:37])[CH2:32][CH2:31]1)=[O:29])[CH2:9][CH2:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][CH2:21][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)=[O:19])[CH2:14][CH2:13]1참가 물질
4
실험 절차
A solution of 1.54 g (3.0 mmol) of phenylmethyl (S)-4-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-5-(4-ethylpiperid-1-yl)-5-oxopentyl]piperidine-1-carboxylate in 60 ml of dichloromethane is treated for 5 min at 0° C. with a stream of hydrogen chloride. After 3 hours at 0° C., the mixture is concentrated under reduced pressure. The resulting product is used without further purification in the following step. 1.35 g of phenylmethyl (S)-4-[4-amino-5-(4-ethylpiperid-1-yl)-5-oxopentyl]piperidine-1-carboxylate hydrochloride are thus obtained in the form of a viscous oil.