Hydrochloric Acid → 4-(7-chloro-2H-benzopyran-3-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride

HRID 1840567노트

반응식

HRID 1840567 반응식
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[CH2:20][CH2:19][N:18]([S:21]([C:24]3[CH2:25][O:26][C:27]4[CH:33]=[C:32]([Cl:34])[CH:31]=[CH:30][C:28]=4[CH:29]=3)(=[O:23])=[O:22])[CH2:17][C:16]2=[O:35])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C.CO>[ClH:34].[Cl:34][C:32]1[CH:31]=[CH:30][C:28]2[CH:29]=[C:24]([S:21]([N:18]3[CH2:19][CH2:20][N:15]([CH2:14][CH:11]4[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]4)[C:16](=[O:35])[CH2:17]3)(=[O:22])=[O:23])[CH2:25][O:26][C:27]=2[CH:33]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 234473471-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(7-chloro-2H-benzopyran-3-sulfonyl)-2-piperazinone

생성물 1

HCID 234473484-(7-chloro-2H-benzopyran-3-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride수율 198.4%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To 1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-4-(7-chloro-2H-benzopyran-3-sulfonyl)-2-piperazinone (1.856 g) were added 4N hydrochloric acid in ethyl acetate (40 ml) and methanol (25 ml), and the mixture was stirred at room temperature for 30 minutes. The reaction solution was concentrated to give colorless crystals of 4-(7-chloro-2H-benzopyran-3-sulfonyl)-1-(piperidin-4-ylmethyl)-2-piperazinone hydrochloride (1.618 g).

후처리

  1. concentrationThe reaction solution was concentrated

출처 및 근거

ORD 기록
ord-ebfb5f75a5ba412b8c6f6705c04fc5f6
출처 데이터셋
uspto-grants-2004_01
특허 번호
US06680312B2

반응 노트

불러오는 중…