Hydrochloric Acid → Methyl 4-methylpiperidine-4-carboxylate hydrochloride
반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH3:17])([C:14]([OH:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:18].[CH3:19]O>>[ClH:18].[CH3:19][O:16][C:14]([C:11]1([CH3:17])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15]참가 물질
4
실험 절차
To a stirred solution of 4-methyl-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1.00 g, 4.10 mmol) in MeOH (2 mL) is added HCl (5 ml, 4 M in dioxane). After 18 h, the mixture is evaporated to dryness, the residue is dissolved in MeOH (3 mL), and the stirred solution is treated with Et2O (45 ml). The resulting solid is filtered and dried to give the title compound.
후처리
- customthe mixture is evaporated to dryness
- dissolutionthe residue is dissolved in MeOH (3 mL)
- additionthe stirred solution is treated with Et2O (45 ml)
- filtrationThe resulting solid is filtered
- customdried
출처 및 근거
- ORD 기록
- ord-b6418eab5117486b93060a13a91ce257
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946203B2
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