Ammonia → Ethyl 3-iminobutanoate

HRID 1842352노트

반응식

HRID 1842352 반응식
[C:1]([O:7][CH2:8][CH3:9])(=[O:6])[CH2:2][C:3]([CH3:5])=O.[NH3:10]>>[NH:10]=[C:3]([CH3:5])[CH2:2][C:1]([O:7][CH2:8][CH3:9])=[O:6]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 8868Ethyl Acetoacetate

생성물 1

HCID 319843Ethyl 3-iminobutanoate수율 85%

실험 절차

A solution of ethyl acetoacetate (50 g, 385 mmol, 1.0 eq) in 25% aqueous ammonia (300 mL) was stirred at room temperature for 1 h then extracted with EtOAc (2×300 mL). The combined organic layers were dried over Na2SO4 and the solvent was removed under reduced pressure to give ethyl 3-iminobutanoate (42 g, 85%) as a yellow oil, which was used directly in the next step.

후처리

  1. extractionthen extracted with EtOAc (2×300 mL)
  2. dry with materialThe combined organic layers were dried over Na2SO4
  3. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-316853aa0d564befa2ea8fc6da03ba74
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946224B2

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