Cesium carbonate → Ethyl 5-(cyclopropylmethyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

HRID 1842471노트

반응식

HRID 1842471 반응식
[CH:1]1([CH2:4]Br)[CH2:3][CH2:2]1.[O:6]=[C:7]1[NH:12][CH2:11][CH2:10][N:9]2[N:13]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:15]=[C:8]12.C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[CH:1]1([CH2:4][N:12]2[CH2:11][CH2:10][N:9]3[N:13]=[C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:15]=[C:8]3[C:7]2=[O:6])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 81503BromomethylcyclopropaneHCID 42873667Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo(1,5-a)pyrazine-2-carboxylate

생성물 1

HCID 58465837Ethyl 5-(cyclopropylmethyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
70 °C

실험 절차

To a solution of cyclopropylmethyl bromide (0.101 g, 0.75 mmol) and ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (31.4 mg, 0.150 mmol) in acetonitrile (2 mL) was added cesium carbonate (147 mg, 0.45 mmol). The reaction mixture was heated overnight at 70° C. Upon cooling to room temperature, the insolubles were removed by filtration and the solvent evaporated to dryness to afford crude Intermediate 33.

후처리

  1. temperatureUpon cooling to room temperature
  2. customthe insolubles were removed by filtration
  3. customthe solvent evaporated to dryness

출처 및 근거

ORD 기록
ord-df742b2d93744e508a5331f72e5a87af
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946223B2

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