p-Toluenesulfonic acid → HCID 71239199, 화합물

HRID 1842736

반응식

HRID 1842736 반응식
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH3:17])[CH:9]=2)[C:5]([CH3:18])=[CH:4][N:3]=1.[F:19][C:20]1[C:26]([N+:27]([O-:29])=[O:28])=[CH:25][C:23]([NH2:24])=[C:22]([O:30][CH3:31])[CH:21]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(O)CCC>[F:19][C:20]1[C:26]([N+:27]([O-:29])=[O:28])=[CH:25][C:23]([NH:24][C:2]2[N:7]=[C:6]([C:8]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[N:10]([CH3:17])[CH:9]=3)[C:5]([CH3:18])=[CH:4][N:3]=2)=[C:22]([O:30][CH3:31])[CH:21]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 574290724-Fluoro-2-methoxy-5-nitroaniline2회HCID 86677338HCID 86677338, 화합물2회

생성물 1

HCID 71239199HCID 71239199, 화합물

시약·촉매·용매 1

HCID 223862-Pentanol용매

반응 조건

온도
125 °C

실험 절차

A mixture of 3-(2-chloro-5-methylpyrimidin-4-yl)-1-methyl-1H-indole (Intermediate 80, 350 mg, 1.36 mmol), 4-fluoro-2-methoxy-5-nitroaniline (Intermediate 23, 265 mg, 1.43 mmol) and p-toluenesulfonic acid (284 mg, 1.49 mmol) in 2-pentanol (25 mL) was heated at 125° C. for 24 h. The mixture was then cooled and concentrated in vacuo. The resulting gum was used without further purification; m/z: ES+ MH+ 240.13.

후처리

  1. temperatureThe mixture was then cooled
  2. concentrationconcentrated in vacuo
  3. customThe resulting gum was used without further purification

출처 및 근거

ORD 기록
ord-c1d648686cb44942b8236cb79171947c
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946235B2

연결된 노트

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