[F:1][C:2]([F:15])([F:14])[C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][NH:9][C:10]2=[O:13])=[CH:5][CH:4]=1.Br[C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1.OC1C=CC=C2C=1N=CC=C2.C(=O)([O-])[O-].[K+].[K+]>[Cu](I)I.CS(C)=O>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([N:9]2[CH:8]=[CH:7][C:6]3[C:11](=[CH:12][C:3]([C:2]([F:1])([F:14])[F:15])=[CH:4][CH:5]=3)[C:10]2=[O:13])[CH:18]=1Using analogous reaction conditions as described in Example 1, 7-trifluoromethyl-2H-isoquinolin-1-one (I-29d: 0.12 g, 0.56 mmol) was reacted with 3-bromo-pyridine (0.106 g, 0.6 mmol), DMSO (2 mL), copper iodide (0.021 g, 0.12 mmol), 8-hydroxy-quinoline (0.018 g, 0.12 mmol) and potassium carbonate (0.15 g, 1.1 mmol) to afford the crude product. Purification by column chromatography on silica gel (0.5% methanol in DCM) afforded 96 mg of the product (70.58% yield).
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