Nitromethane → 1,2-Dichloro-4-[(E)-2-nitroethenyl]benzene
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH:5]=O.[N+:11]([CH3:14])([O-:13])=[O:12].[OH-].[Na+]>C(O)C>[Cl:10][C:9]1[CH:8]=[CH:7][C:4](/[CH:5]=[CH:14]/[N+:11]([O-:13])=[O:12])=[CH:3][C:2]=1[Cl:1]참가 물질
5
실험 절차
Using analogous conditions and workup as described for the preparation of intermediate I-1a above, 3,4-dichlorobenzaldehyde (10 g, 74.074 mmol) in ethanol (100 mL) was reacted with nitro methane (4.12 mL, 74.074 mmol) and 10N NaOH (2.96 g in 7.4 mL of H2O, 74.074 mmol) to afford 6.2 g of the product (39% yield).
후처리
- customas described for the preparation of intermediate
출처 및 근거
- ORD 기록
- ord-c74a5dc2564f4166bbc319471dbfdaad
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946260B2
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