3-(3-Fluorophenyl)-2-propenoic acid → 3-(3-Fluorophenyl)propionic acid

HRID 1844045

반응식

HRID 1844045 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1>CO.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 886063-(3-Fluorophenyl)-2-propenoic acid

생성물 1

HCID 27374893-(3-Fluorophenyl)propionic acid수율 80.69%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

3-(3-Fluorophenyl)acrylic acid (I-78a: 6.4 gm, 38.5 mmol) in methanol (100 mL) was reduced with 10% Pd/C (640 mg) to afford the crude product, 5 g (80.69% yield).

출처 및 근거

ORD 기록
ord-7a510fce0be64052bf67aa17848ce7a5
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946260B2

연결된 노트

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