Hydrochloric Acid → Methyl 6,6,6-trifluoro-5-hydroxynorleucinate hydrochloride
반응식
[ClH:1].[F:2][C:3]([F:14])([F:13])[CH:4]([OH:12])[CH2:5][CH2:6][C@@H:7]([C:9]([OH:11])=[O:10])[NH2:8].[CH3:15]O>>[ClH:1].[F:2][C:3]([F:13])([F:14])[CH:4]([OH:12])[CH2:5][CH2:6][C@@H:7]([C:9]([O:11][CH3:15])=[O:10])[NH2:8]참가 물질
4
실험 절차
1.4 ml of saturated hydrochloric acid in methanol were added to 150 mg (0.7 mmol) of rac-6,6,6-trifluoro-5-hydroxynorleucine (stereoisomer mixture), and the mixture was stirred under reflux overnight. The reaction solution was concentrated, another 1.5 ml of saturated hydrochloric acid in methanol were added and the mixture was stirred under reflux overnight. The reaction solution was concentrated and the residue was dried under high vacuum. This gave 185 mg (99% of theory) of the target compound.
후처리
- temperatureunder reflux overnight
- concentrationThe reaction solution was concentrated
- additionanother 1.5 ml of saturated hydrochloric acid in methanol were added
- stirringthe mixture was stirred
- temperatureunder reflux overnight
- concentrationThe reaction solution was concentrated
- customthe residue was dried under high vacuum
출처 및 근거
- ORD 기록
- ord-fccb93fb15a0462990f4a2d05e95feab
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946215B2
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