Hydrochloric Acid → (R)-4-(3,4-dichlorophenyl)butan-2-amine hydrochloride

HRID 1844422노트

반응식

HRID 1844422 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C@H:11]([NH:13][S@](C(C)(C)C)=O)[CH3:12])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.CC(S(OC)=O)(C)C>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][C@H:11]([NH2:13])[CH3:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 543690Methyl 2-methylpropane-2-sulfinateHCID 86731088(S)-N-((R)-4-(3,4-dichlorophenyl)butan-2-yl)-2-methylpropane-2-sulfinamide

생성물 1

HCID 86731090(R)-4-(3,4-dichlorophenyl)butan-2-amine hydrochloride수율 195%

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매

실험 절차

(S)-N-((R)-4-(3,4-Dichlorophenyl)butan-2-yl)-2-methylpropane-2-sulfinamide (600 mg, 1.862 mmol) was stirred in MeOH (10 mL) at rt. 4N HCl in dioxane (5 mL) was added. The resulting mixture was stirred at rt for 20 min. The solvents were evaporated and CH2Cl2 (3×) was added and evaporated. The resulting white solids were vacuum dried for 5 h to give (R)-4-(3,4-dichlorophenyl)butan-2-amine hydrochloride (462 mg, 1.815 mmol, 97% yield) as off-white solids and methyl 2-methylpropane-2-sulfinate. The HCl salt was used without further purification. LC-MS (ESI) m/z 218.0 (M+H), RT=1.61 min (Method B).

후처리

  1. customThe solvents were evaporated
  2. additionCH2Cl2 (3×) was added
  3. customevaporated
  4. customdried for 5 h

출처 및 근거

ORD 기록
ord-5dde90ca36fa4799bb65d4894654b4b7
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946430B2

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