Propargyl bromide → 1-[(Prop-2-yn-1-yl)oxy]-2-(trifluoromethyl)benzene
반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].[CH:12]#[C:13][CH2:14]Br.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH2:14]([O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:10])([F:11])[F:1])[C:13]#[CH:12]참가 물질
5
실험 절차
To a stirred solution of 2-(trifluoromethyl)phenol (50.0 g, 0.31 mol) and progargyl bromide (44.0 g, 0.37 mol) in ACN (500 mL) was added K2CO3 (51.0 g, 0.37 mol) and the mixture was stirred overnight at rt, concentrated, diluted with water and extracted with Et2O. The combined organic layers were dried over Na2SO4, filtered, concentrated and purified by CC (PE/EA=40/1) to give compound P33a (59.7 g, 97%) as an oil.
후처리
- concentrationconcentrated
- additiondiluted with water
- extractionextracted with Et2O
- dry with materialThe combined organic layers were dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- custompurified by CC (PE/EA=40/1)
- customto give compound P33a (59.7 g, 97%) as an oil
출처 및 근거
- ORD 기록
- ord-7153c67ecf21467cbf3c81b45529fe39
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946446B2
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