Methanol → N-(tert-Butyl)-1H-pyrrole-3-sulfonamide
반응식
[C:1]([NH:5][S:6]([C:9]1[CH:13]=[CH:12][N:11](S(C2C=CC(C)=CC=2)(=O)=O)[CH:10]=1)(=[O:8])=[O:7])([CH3:4])([CH3:3])[CH3:2].CO.O.C([O-])([O-])=O.[K+].[K+]>C1COCC1.CC(O)=O>[C:1]([NH:5][S:6]([C:9]1[CH:13]=[CH:12][NH:11][CH:10]=1)(=[O:8])=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
7
반응 조건
- 온도
- 60 °C
실험 절차
To a solution of compound 27c (665 mg, 1.87 mmol) in a mixture of THF (12 mL), MeOH (12 mL) and water (3 mL) was added K2CO3 (3.1 g, 22 mmol) and then the solution was heated at 60° C. overnight, cooled, acidified to pH=5 with AcOH and extracted with EA twice. The combined organic layers were washed with water (3×) and brine, concentrated and purified by CC (PE/EA=2/1) to give compound 27d (260 mg, 69%) as a solid.
후처리
- temperaturecooled
- extractionextracted with EA twice
- washThe combined organic layers were washed with water (3×) and brine
- concentrationconcentrated
- custompurified by CC (PE/EA=2/1)
출처 및 근거
- ORD 기록
- ord-23659cd8d00544bf89aaaa18cadb6b73
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08946446B2
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