Lithium Hydroxide → 2-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid

HRID 1845098노트

반응식

HRID 1845098 반응식
C[O:2][C:3]([C:5]1[C:13]2[O:12][C:11]([NH:14][C:15]([C:17]3[N:18]=[CH:19][C:20]4[C:25]([CH:26]=3)=[CH:24][CH:23]=[CH:22][CH:21]=4)=[O:16])=[N:10][C:9]=2[CH:8]=[CH:7][CH:6]=1)=[O:4].[Li+].[OH-].C1COCC1>CO>[CH:19]1[C:20]2[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:26]=[C:17]([C:15]([NH:14][C:11]2[O:12][C:13]3[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=[CH:8][C:9]=3[N:10]=2)=[O:16])[N:18]=1

참가 물질

5

반응물 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 669403112-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid methyl ester

생성물 1

HCID 669404902-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-[(Isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid was synthesized according to General Procedure B using 417 mg (1.2 mmol) 2-[(isoquinoline-3-carbonyl)-amino]-benzooxazole-7-carboxylic acid methyl ester, 2.4 mL of 2 N aq. LiOH, 12 mL of THF and 3 mL of methanol at 40° C. for 4 h. 141 mg (0.423 mmol, 35%) of the product was obtained. LCMS: 334 (M+1)+.

후처리

  1. customat 40° C.
  2. customfor 4 h

출처 및 근거

ORD 기록
ord-a7ef4fc138bc40cdb4a5afab6a895f96
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946259B2

반응 노트

불러오는 중…