Methanol → 6-Cyanobenzo[b]thiophene-2-carboxylic acid

HRID 1845125노트

반응식

HRID 1845125 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[S:8][C:7]=2[CH:15]=1)#[N:2].CO.[OH-].[Na+]>O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[S:8][C:7]=2[CH:15]=1)#[N:2]

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 11031280Methyl 6-cyanobenzo[b]thiophene-2-carboxylate

생성물 1

HCID 106796506-Cyanobenzo[b]thiophene-2-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A round bottom flask was charged with methyl 6-cyanobenzo[b]thiophene-2-carboxylate (4.00 g, 17.9 mmol), methanol (130 mL), and sodium hydroxide (23 g, 0.58 mol) in water (200 mL). The reaction was stirred at room temperature for 20 minutes. The reaction was concentrated to half of the volume and acidified with 6 N aq. HCl. The mixture was extracted with CHCl3/i-PrOH (90:10) and the organic phase was concentrated under reduced pressure to get the title compound as a brown solid.

후처리

  1. concentrationThe reaction was concentrated to half of the volume
  2. extractionThe mixture was extracted with CHCl3/i-PrOH (90:10)
  3. concentrationthe organic phase was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a3fec847502f49579489f56ed53ec9b1
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

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