Hydrochloric Acid → Benzo[b]thiophene-6-carbonitrile

HRID 1845126노트

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HRID 1845126 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[CH:10]=[C:9](C(O)=O)[S:8][C:7]=2[CH:14]=1)#[N:2].N12CCCN=C1CCCCC2.Cl>CN(C)C(=O)C>[S:8]1[CH:9]=[CH:10][C:6]2[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:14][C:7]1=2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 106796506-Cyanobenzo[b]thiophene-2-carboxylic acid

생성물 1

HCID 21816574Benzo[b]thiophene-6-carbonitrile

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A microwave vial was charged with 6-cyanobenzo[b]thiophene-2-carboxylic acid (1.90 g, 9.35 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (5.6 mL, 37.4 mmol) and N,N-dimethylacetamide (15 mL) and the reaction was subjected to microwave irradiation at 190° C. for 1 hour. After cooling, the reaction mixture was poured into 1N aq. HCl and extracted with ethyl acetate. The organic phase was concentrated under reduced pressure to get the product as light brown solid.

후처리

  1. customirradiation at 190° C. for 1 hour
  2. temperatureAfter cooling
  3. extractionextracted with ethyl acetate
  4. concentrationThe organic phase was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-524232558f104bde85cd2a4ee03859a5
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

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