Pyridine → 3-Iodo-2-methyl-5-(pyrrolidin-1-ylsulfonyl)benzoic acid

HRID 1845204노트

반응식

HRID 1845204 반응식
Cl[S:2]([C:5]1[CH:6]=[C:7]([I:15])[C:8]([CH3:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.N1C=CC=CC=1>O1CCOCC1>[I:15][C:7]1[C:8]([CH3:14])=[C:9]([CH:13]=[C:5]([S:2]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)(=[O:4])=[O:3])[CH:6]=1)[C:10]([OH:12])=[O:11]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 31268PyrrolidineHCID 581880135-(Chlorosulfonyl)-3-iodo-2-methylbenzoic acid

생성물 1

HCID 581883403-Iodo-2-methyl-5-(pyrrolidin-1-ylsulfonyl)benzoic acid

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A round bottom flask was charged with 5-(chlorosulfonyl)-3-iodo-2-methylbenzoic acid (1.00 g, 2.77 mmol), pyrrolidine (0.278 mL, 3.33 mmol), 1,4-dioxane (4 mL) and pyridine (0.20 mL, 2.5 mmol). The mixture was stirred for 30 minutes. The solvent was removed and the residue was purified by flash chromatography to yield the compound as a yellow solid.

후처리

  1. customThe solvent was removed
  2. customthe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-21161e9b79f34633964e57838a671d76
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

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