Tetrahydrofurfuryl alcohol → Methyl 4'-methyl-5-((tetrahydrofuran-2-yl)methoxy)biphenyl-3-carboxylate

HRID 1845316노트

반응식

HRID 1845316 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:15]([O:17][CH3:18])=[O:16])[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[CH:7]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[O:38]1[CH2:42][CH2:41][CH2:40][CH:39]1[CH2:43]O.N(C(OC(C)C)=O)=NC(OC(C)C)=O>C(Cl)Cl>[CH3:14][C:11]1[CH:10]=[CH:9][C:8]([C:6]2[CH:7]=[C:2]([O:1][CH2:43][CH:39]3[CH2:40][CH2:41][CH2:42][O:38]3)[CH:3]=[C:4]([C:15]([O:17][CH3:18])=[O:16])[CH:5]=2)=[CH:13][CH:12]=1

참가 물질

6

반응물 4

HCID 7360Tetrahydrofurfuryl alcoholHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 58187967Methyl 5-hydroxy-4'-methyl-[1,1'-biphenyl]-3-carboxylate

생성물 1

HCID 58187973Methyl 4'-methyl-5-((tetrahydrofuran-2-yl)methoxy)biphenyl-3-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a stirred solution of methyl 5-hydroxy-4′-methylbiphenyl-3-carboxylate (150 mg, 0.59 mmol), triphenylphosphine (150 mg, 0.59 mmol), tetrahydro-2-furanmethanol (60 mg, 0.59 mmol) in CH2Cl2 (8 mL) at rt was slowly added a solution of diisopropyl azodicarboxylate (200 mg, 1.0 mmol) in CH2Cl2 (3 mL). The mixture was stirred at room temperature overnight, and then concentrated in vacuo. The residue was purified by flash chromatography to afford the title compound.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue was purified by flash chromatography

출처 및 근거

ORD 기록
ord-09489a175fb842d98f020a1074b6f0d9
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08946439B2

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