Ammonium Chloride → 1-(2-Aminopyrimidin-4-yl)ethanol
반응식
[NH2:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][N:3]=1.[BH4-].[Na+].[Cl-].[NH4+]>CO>[NH2:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][N:3]=1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
1-(2-aminopyrimidin-4-yl)ethanone (Compound 3a) (0.5 g) was dissolved in 50 mL methanol and cooled to 0° C. Sodium borohydride (0.138 g) was added portion wise and the mixture was stirred for 16 hours at room temperature. Saturated ammonium chloride solution (20 mL) was added and this mixture was extracted twice with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and evaporated to give the title compound (270 mg) as a colourless oil that solidified on standing.
후처리
- extractionthis mixture was extracted twice with ethyl acetate
- washThe combined organic layers were washed with brine
- dry with materialdried over sodium sulfate
- customevaporated
출처 및 근거
- ORD 기록
- ord-d4e5eedf93cc4a08aed9cd57ee5105c9
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08952001B2
반응 노트
불러오는 중…