Hydrazine hydrate (1:1) → 1-(2-Hydrazinopyridin-4-yl)ethanol
반응식
Cl[C:2]1[CH:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][N:3]=1.O.[NH2:12][NH2:13]>CO.CCOCC>[NH:12]([C:2]1[CH:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][N:3]=1)[NH2:13]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
1-(2-chloropyridin-4-yl)ethanol (5d) (14.3 g) was dissolved in hydrazine hydrate (275 mL). The resulting mixture was heated at 100° C. with stirring overnight. The mixture was concentrated under vacuum to give a yellow oil that was dissolved in a small volume of methanol and ether was added, which resulted in precipitation of a white solid. The obtained suspension was stirred for 30 minutes and filtered, and the residue (hydrazine hydrochloride) was discarded. The filtrate was concentrated under vacuum to give the title compound (13.7 g) as a light-brown oil.
후처리
- concentrationThe mixture was concentrated under vacuum
- customto give a yellow oil that
- additionwas added
- customwhich resulted in precipitation of a white solid
- stirringThe obtained suspension was stirred for 30 minutes
- filtrationfiltered
- concentrationThe filtrate was concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-f10144315593443384fb8eac4ba5b9ee
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08952001B2
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