1-(4-Amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol → 1-(4-Amino-1,3,5-triazin-2-yl)ethanol

HRID 1845869노트

반응식

HRID 1845869 반응식
[NH2:1][C:2]1[N:7]=[C:6](SC)[N:5]=[C:4]([CH:10]([OH:12])[CH3:11])[N:3]=1>C(O)C.[Ni].O>[NH2:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([CH:10]([OH:12])[CH3:11])[N:3]=1

참가 물질

5

반응물 1

HCID 672579331-(4-Amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol

생성물 1

HCID 672560701-(4-Amino-1,3,5-triazin-2-yl)ethanol수율 76.8%

시약·촉매·용매 3

HCID 935Nickel촉매HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
85 °C

실험 절차

To a solution of 1-(4-amino-6-(methylthio)-1,3,5-triazin-2-yl)ethanol (398 mg) in ethanol (20 mL) was added Raney nickel 50% slurry in water (6 mL) and the reaction mixture was heated to 85° C. for 30 minutes then cooled to room temperature, filtered and evaporated to give the title compound (230 mg).

후처리

  1. temperaturethen cooled to room temperature
  2. filtrationfiltered
  3. customevaporated

출처 및 근거

ORD 기록
ord-4e8caa51a2e446d591c607c667a83b3b
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952001B2

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