Hydrochloric Acid → 5-Chlorothiazolo[5,4-b]pyridin-2(1H)-one
반응식
[Cl:1][C:2]1[N:7]=[C:6]2[S:8][C:9]([O:11]C)=[N:10][C:5]2=[CH:4][CH:3]=1.O1CCOCC1.Cl>O>[Cl:1][C:2]1[N:7]=[C:6]2[S:8][C:9](=[O:11])[NH:10][C:5]2=[CH:4][CH:3]=1참가 물질
5
반응 조건
- 온도
- 95 °C
실험 절차
To round bottom flask was added give 5-chloro-2-methoxy[1,3]thiazolo[5,4-b]pyridine (1-3) (5.76 g, 28.7 mmol), 1,4-dioxane (90 mL), and a 6N solution of HCl in water (23.9 mL, 144 mmol). The reaction mixture was then heated to 95° C. while stirring in a hot oil bath with a water cooled reflux condenser attached under an atmosphere of nitrogen for 20 minutes. The crude reaction mixture was then allowed to cool to room temperature, diluted methanol and concentrated to give 5-chloro[1,3]thiazolo[5,4-b]pyridin-2(1H)-one (1-4) as a tan solid. HRMS (M+H)+: observed=186.9731, calculated=186.9727.
후처리
- additionTo round bottom flask was added
- temperaturecooled
- temperaturereflux condenser
- customThe crude reaction mixture
- temperatureto cool to room temperature
- concentrationdiluted methanol and concentrated
출처 및 근거
- ORD 기록
- ord-447eba502ec9487a979bd8372ba91c6e
- 출처 데이터셋
- uspto-grants-2015_02
- 특허 번호
- US08952005B2
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