Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole → 5-Amino-N-(3-chloro-5-fluoro-phenyl)-2-(2,2-difluoro-ethoxy)-nicotinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4,6-Dibromo-2,3-bis(methylsulfanyl)-1H-indole | HCID 14185853 | — |
| 반응물 | N-(3-chloro-5-fluoro-phenyl)-2-(2,2-difluoroethoxy)-5-nitro-nicotinamide | HCID 58483304 | — |
| 촉매 | HCID 178506447 | HCID 178506447 | — |
| 생성물 | 5-Amino-N-(3-chloro-5-fluoro-phenyl)-2-(2,2-difluoro-ethoxy)-nicotinamide | HCID 58483396 | — |
반응 단계
Prepared analogously to example 6d with N-(3-chloro-5-fluoro-phenyl)-2-(2,2-difluoroethoxy)-5-nitro-nicotinamide (230 mg; 0.61 mmol); Ra-Ni/H2 (50 mg; 3 bar) in 8 mL. Yield: quantitative; MS: [M+H]+=346 (Cl isotope pattern); HPLC: Rt=2.1 min (Method MC-6)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08951999B2 |
| 출처 데이터셋 | uspto-grants-2015_02 |
| ORD ID | ord-a46a342353504298a3948ffdbafdc43f |
| 출처 메모 | uspto-grants-2015_02 |