Benzaldehyde, 2-hydroxy-5-methyl- → 2-[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

HRID 18462

반응식

HRID 18462 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][NH2:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[OH:10][C:11]1[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][C:12]=1[CH:13]=O.C[Si]([N:24]=[N+:25]=[N-:26])(C)C.[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][N+:35]#[C-:36])=[CH:30][CH:29]=1>CO>[Cl:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][N:35]2[C:36]([CH:13]([NH:9][CH2:8][CH2:7][CH2:6][N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)[C:12]3[CH:15]=[C:16]([CH3:19])[CH:17]=[CH:18][C:11]=3[OH:10])=[N:26][N:25]=[N:24]2)=[CH:30][CH:29]=1

참가 물질

6

반응물 4

HCID 69184Benzaldehyde, 2-hydroxy-5-methyl-HCID 78378AzidotrimethylsilaneHCID 787361H-Imidazole-1-propanamineHCID 27574091-Chloro-4-(isocyanomethyl)benzene

생성물 1

HCID 250622412-[[1-(4-Chloro-benzyl)-1H-tetrazol-5-yl]-(3-imidazol-1-yl-propylamino)-methyl]-4-methyl-phenol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

3-Imidazol-1-yl-propylamine (1 mmol) and 2-Hydroxy-5-methyl-benzaldehyde (1 mmol) were combined in methanol (2 ml, dry). After 2 hours Trimethylsilylazide (5 mmol) and 1-Chloro-4-isocyanomethyl-benzene (1 mmol) was added. The reaction was stirred at room temperature for 48 h. After evaporation of the solvent the residue was purified with chromatographic methods.

후처리

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

출처 및 근거

ORD 기록
ord-9eb22706214142e0979a67926478b28b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741354B2

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