Di-tert-butyl dicarbonate → HCID 89964282, 화합물

HRID 1846234노트

반응식

HRID 1846234 반응식
[CH2:1]([N:4]([C:12]1[C:13](Br)=[N:14][CH:15]=[CH:16][CH:17]=1)[C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8])[CH:2]=C.C(NC1C(Br)=NC=CC=1)C=C.CC([O:34]C(OC(OC(C)(C)C)=O)=O)(C)C>C(Cl)Cl>[O:34]=[C:2]1[C:13]2=[N:14][CH:15]=[CH:16][CH:17]=[C:12]2[N:4]([C:5]([O:6][C:7]([CH3:8])([CH3:9])[CH3:10])=[O:11])[CH2:1]1

참가 물질

5

반응물 3

HCID 90495Di-tert-butyl dicarbonateHCID 89964062HCID 89964062, 화합물HCID 89964404HCID 89964404, 화합물

생성물 1

HCID 89964282HCID 89964282, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-butyl allyl(2-bromopyridin-3-yl)carbamate. To a solution of N-allyl-2-bromopyridin-3-amine (1 eq.) and DCM (0.2 M) is added (Boc)2O (1.5 eq.). The solution is stirred at room temperature until judged complete by TLC. The solution is concentrated in vacuo and purified by column chromatography to give the title compound.

후처리

  1. concentrationThe solution is concentrated in vacuo
  2. custompurified by column chromatography

출처 및 근거

ORD 기록
ord-af0b2763c8034ad091406bc7813507cb
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952009B2

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