4,6-Dichloropyrimidine → 6-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

HRID 1846428노트

반응식

HRID 1846428 반응식
[NH2:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[O:8][C:4]=2[CH:3]=1.[Cl:13][C:14]1[CH:19]=[C:18](Cl)[N:17]=[CH:16][N:15]=1>C(O)CCC>[Cl:13][C:14]1[N:15]=[CH:16][N:17]=[C:18]([NH:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[O:8][C:4]=3[CH:3]=2)[CH:19]=1

참가 물질

4

반응물 2

HCID 709434,6-DichloropyrimidineHCID 199116046-Amino-4-methyl-1,3-benzoxazol-2(3H)-one

생성물 1

HCID 866638946-(6-chloro-pyrimidin-4-ylamino)-4-methyl-3H-benzoxazol-2-one

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

400 mg (2.40 mmol) 6-amino-4-methyl-3H-benzoxazol-2-one, 400 mg (2.70 mmol) 4,6-dichloropyrimidine and 1.10 mL (8.00 mmol) TEA in 5 mL 1-butanol were stirred for 1 h at 100° C. After cooling to RT the reaction mixture was evaporated down and the residue was washed with water and saturated sodium hydrogen carbonate solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

후처리

  1. customwas evaporated down
  2. washthe residue was washed with water and saturated sodium hydrogen carbonate solution
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

출처 및 근거

ORD 기록
ord-ea34a53c021d48cf9ce0601b0b40583a
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

반응 노트

불러오는 중…