4,6-Diiodopyrimidine → (6-iodo-pyrimidin-4-yl)-(1,2,7-trimethyl-1H-benzimidazol-5-yl)-amine

HRID 1846440노트

반응식

HRID 1846440 반응식
Cl.[CH3:2][N:3]1[C:7]2[C:8]([CH3:13])=[CH:9][C:10]([NH2:12])=[CH:11][C:6]=2[N:5]=[C:4]1[CH3:14].[I:15][C:16]1[CH:21]=[C:20](I)[N:19]=[CH:18][N:17]=1>C(O)CCC>[I:15][C:16]1[N:17]=[CH:18][N:19]=[C:20]([NH:12][C:10]2[CH:9]=[C:8]([CH3:13])[C:7]3[N:3]([CH3:2])[C:4]([CH3:14])=[N:5][C:6]=3[CH:11]=2)[CH:21]=1

참가 물질

4

반응물 2

HCID 157602954,6-DiiodopyrimidineHCID 669781471,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride

생성물 1

HCID 86663900(6-iodo-pyrimidin-4-yl)-(1,2,7-trimethyl-1H-benzimidazol-5-yl)-amine

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

150 mg (0.700 mmol) 1,2,7-trimethyl-1H-benzimidazol-5-ylamine hydrochloride, 260 mg (0.800 mmol) 4,6-diiodopyrimidine, 0.300 mL (2.00 mmol) TEA and 5.0 mL 1-butanol were combined and stirred for 1 h at RT. The reaction mixture was evaporated down and the residue was extracted with DCM and 1N aqueous sodium hydroxide solution. The organic phase was dried on sodium sulphate, filtered and evaporated down.

후처리

  1. customThe reaction mixture was evaporated down
  2. extractionthe residue was extracted with DCM and 1N aqueous sodium hydroxide solution
  3. customThe organic phase was dried on sodium sulphate
  4. filtrationfiltered
  5. customevaporated down

출처 및 근거

ORD 기록
ord-bfcbd8a1236646ef9474dec19935d0ea
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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