4-Acetylamino-3-methyl-5-nitro-phenyl acetate → 4-Amino-3-methyl-5-nitrophenol

HRID 1846451노트

반응식

HRID 1846451 반응식
C([O:4][C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[C:8]([NH:14]C(=O)C)=[C:7]([CH3:18])[CH:6]=1)(=O)C>Cl>[NH2:14][C:8]1[C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]([OH:4])=[CH:6][C:7]=1[CH3:18]

참가 물질

3

반응물 1

HCID 669782344-Acetylamino-3-methyl-5-nitro-phenyl acetate

생성물 1

HCID 669782964-Amino-3-methyl-5-nitrophenol

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

20.4 g (80.7 mmol) 4-acetylamino-3-methyl-5-nitro-phenyl acetate in 100 mL semi-concentrated aqueous hydrochloric acid were refluxed for 2 h. Then the reaction mixture was evaporated down, the residue was triturated with acetone and suction filtered. After washing with acetone and diethyl ether the precipitate was dried under HV. The mother liquor was evaporated down, the residue was taken up in water and freeze-dried.

후처리

  1. customThen the reaction mixture was evaporated down
  2. customthe residue was triturated with acetone and suction
  3. filtrationfiltered
  4. washAfter washing with acetone and diethyl ether the precipitate
  5. customwas dried under HV
  6. customThe mother liquor was evaporated down
  7. customfreeze-dried

출처 및 근거

ORD 기록
ord-1537f24eb5eb4816a570794d73224cec
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952014B2

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