Trifluoroacetic acid → Trifluoroacetic acid

HRID 1846741

반응식

HRID 1846741 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([NH:7]C(=O)OC(C)(C)C)[S:5][CH:6]=1.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[CH3:1][C:2]1[CH:3]=[C:4]([NH2:7])[S:5][CH:6]=1.[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 574719832-(Boc-amino)-4-methylthiophene

생성물 2

HCID 6422Trifluoroacetic acidHCID 122311924-Methylthiophen-2-amine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of tert-butyl 4-methylthiophen-2-ylcarbamate (0.880 g, 4.13 mmol) in CH2Cl2 (8 mL) and TFA (6 mL) wad stirred at room temperature for 3 h. Solvents was removed in vacuo to give 4-methylthiophen-2-amine as trifluoroacetic acid salt (0.920 g).

후처리

  1. customSolvents was removed in vacuo

출처 및 근거

ORD 기록
ord-5af6f8ec47ba49238569a926d5c0d60f
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952027B2

연결된 노트

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