Hydrochloric Acid → 3-((3-Bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride

HRID 1846769노트

반응식

HRID 1846769 반응식
[Br:1][C:2]1[C:3]([O:8][CH:9]2[CH2:12][CH:11]([NH:13]C(=O)OC(C)(C)C)[CH2:10]2)=[N:4][CH:5]=[CH:6][CH:7]=1.[ClH:21]>CO>[ClH:21].[Br:1][C:2]1[C:3]([O:8][CH:9]2[CH2:10][CH:11]([NH2:13])[CH2:12]2)=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58548513Tert-butyl (3-((3-bromopyridin-2-yl)oxy)cyclobutyl)carbamate

생성물 1

HCID 674787263-((3-Bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To tert-butyl (3-((3-bromopyridin-2-yl)oxy)cyclobutyl)carbamate (see PREPARATION 7B; 342 mg, 1 mmol) was added 4 M HCl in MeOH (50 mL). The solution was stirred at RT for 2 hours. The solvent was removed under reduced pressure to give 3-((3-bromopyridin-2-yl)oxy)cyclobutanamine hydrochloride (223 mg, 0.95 mmol, yield 95%). ESI-MS (M+1): 243 calc. for C9H11BrN2O 242.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-edc6690e987a4e77b2c19b9cd03ebe42
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952037B2

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