Hydrochloric Acid → 3-(7-Methoxy-2-oxoquinoxalin-1(2H)-yl)propanal

HRID 1846997노트

반응식

HRID 1846997 반응식
C[O:2][CH:3](OC)[CH2:4][CH2:5][N:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH3:17])[CH:14]=2)[N:9]=[CH:8][C:7]1=[O:18].Cl>O1CCCC1.ClCCl>[CH3:17][O:16][C:13]1[CH:14]=[C:15]2[C:10]([N:9]=[CH:8][C:7](=[O:18])[N:6]2[CH2:5][CH2:4][CH:3]=[O:2])=[CH:11][CH:12]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 867249271-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one

생성물 1

HCID 867249283-(7-Methoxy-2-oxoquinoxalin-1(2H)-yl)propanal수율 94.1%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

1-(3,3-Dimethoxypropyl)-7-methoxyquinoxalin-2(1H)-one (300 mg, 1.08 mmol) was dissolved in tetrahydrofuran (3 ml). 1N Hydrochloric acid (3 ml) was added to this solution and the mixture was stirred at room temperature for 3.5 hours. The reaction solution was diluted with dichloromethane and stirred, and the organic layer was then separated. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate and then the solvent was removed under reduced pressure to yield 236 mg (94%) of the title compound in the form of a light brown solid.

후처리

  1. stirringstirred
  2. customthe organic layer was then separated
  3. washThe organic layer was washed with saturated sodium chloride solution
  4. dry with materialdried over magnesium sulfate
  5. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-5af76eacfffa47a8bb64741ab3074d97
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952010B2

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