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Triethylamine → HCID 46830922, 화합물

HRID 1848346
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HRID 1848346 반응식
[OH:1][CH2:2][C:3]1([C:6]2[N:24]=[C:9]3[C:10]([O:22][CH3:23])=[CH:11][CH:12]=[C:13]([C:14]4[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=4)[C:17]#[N:18])[N:8]3[N:7]=2)[CH2:5][CH2:4]1.CCN(CC)CC.[CH:32]([N:35]=[C:36]=[O:37])([CH3:34])[CH3:33]>CC#N>[C:17]([C:16]1[CH:15]=[C:14]([C:13]2[N:8]3[N:7]=[C:6]([C:3]4([CH2:2][O:1][C:36](=[O:37])[NH:35][CH:32]([CH3:34])[CH3:33])[CH2:5][CH2:4]4)[N:24]=[C:9]3[C:10]([O:22][CH3:23])=[CH:11][CH:12]=2)[CH:21]=[CH:20][CH:19]=1)#[N:18]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471Triethylamine2회HCID 61277Isopropyl isocyanate2회HCID 46830920HCID 46830920, 화합물2회

생성물 1

HCID 46830922HCID 46830922, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
65 °C

실험 절차

Under an argon atmosphere 3-[2-(1-Hydroxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-benzonitrile (compound 150) (0.03 g, 0.08 mmol) was dissolved in CH3CN (1 mL). Et3N (0.005 mL) and isopropyl isocyanate (0.04 mL) were added and the reaction mixture was shaken at 65° C. for 20 H. Et3N (0.005 mL) and isopropyl isocyanate (0.04 mL) were added again and the reaction mixture was shaken at 65° C. for another 24 H. The solvent was evaporated and the crude product was purified by flash chromatography on silica using DCM:MeOH 99:1 as eluent to afford the title compound as a solid.

후처리

  1. stirringthe reaction mixture was shaken at 65° C. for another 24 H
  2. customThe solvent was evaporated
  3. customthe crude product was purified by flash chromatography on silica

출처 및 근거

ORD 기록
ord-42236cc6ffe54641b2c0f6318c31aee8
출처 데이터셋
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08952162B2

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