Hydrochloric Acid → 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride

HRID 1848823

반응식

HRID 1848823 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:21]>ClCCl>[ClH:21].[ClH:21].[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

생성물 1

HCID 451567511-(Oxan-4-yl)piperidin-4-amine dihydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of EXAMPLE 49A (52.57 g) in dichloromethane (900 mL) was treated with 4M aqueous HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

후처리

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-2fd778e07d3a4ec5b34cb3cc13935c2e
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952157B2

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