Piperazine → 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester

HRID 1848906노트

반응식

HRID 1848906 반응식
[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7](F)=[CH:6][C:5]=1[O:11][C:12]1[C:20]2[N:19]=[N:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1.[NH:31]1[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]1.ClCCl>CS(C)=O>[CH3:1][O:2][C:3](=[O:30])[C:4]1[CH:9]=[CH:8][C:7]([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[CH:6][C:5]=1[O:11][C:12]1[C:20]2[N:19]=[N:18][N:17]([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][CH:23]=3)[C:16]=2[CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 3

HCID 4837PiperazineHCID 6344DichloromethaneHCID 672269974-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester

생성물 1

HCID 672279252-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
100 °C

실험 절차

To a solution of EXAMPLE 342D (650 mg) in dimethylsulfoxide (12 mL) was added piperazine (618 mg). The solution was heated at 100° C. for one hour, cooled, added to dichloromethane, extracted with water three times, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under vacuum.

후처리

  1. temperaturecooled
  2. extractionextracted with water three times
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customthe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-50f992168f3144e3926f8921efb71ecd
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08952157B2

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