Sodium borohydride → [2-(4-Chlorophenyl)thiazol-5-yl]methanol

HRID 1849974노트

반응식

HRID 1849974 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([CH:13]=[O:14])=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH2:13][OH:14])=[CH:11][N:12]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 450368222-(4-Chlorophenyl)-1,3-thiazole-5-carbaldehyde

생성물 1

HCID 59562416[2-(4-Chlorophenyl)thiazol-5-yl]methanol수율 98.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a suspension of 2-(4-chlorophenyl)thiazole-5-carbaldehyde (3.26 g, 14.6 mmol) in methanol (50 ml) is added the sodium borohydride (568 mg, 15 mmol) portionwise at room temperature. The reaction mixture is stirred at room temperature for 2 h. The reaction mixture is quenched with 50 ml of an aqueous saturated solution of ammonium chloride, extracted with dichloromethane (2×100 ml). The combined organic extracts are dried with magnesium sulphate, filtered and evaporated to dryness to give [2-(4-chlorophenyl)thiazol-5-yl]methanol (3.24 g).

후처리

  1. customThe reaction mixture is quenched with 50 ml of an aqueous saturated solution of ammonium chloride
  2. extractionextracted with dichloromethane (2×100 ml)
  3. dry with materialThe combined organic extracts are dried with magnesium sulphate
  4. filtrationfiltered
  5. customevaporated to dryness

출처 및 근거

ORD 기록
ord-31e7fe97978645ac95802f4f75d84ec1
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08956999B2

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