Hydrochloric Acid → 2,6-Dimethyl-L-tyrosyl-N-[(2R)-2-amino-3-phenylpropyl]-D-alaninamide

HRID 1849990

반응식

HRID 1849990 반응식
C(OC([NH:8][C@H:9]([C:20]([NH:22][C@@H:23]([C:25]([NH:27][CH2:28][C@H:29]([NH2:37])[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:26])[CH3:24])=[O:21])[CH2:10][C:11]1[C:16]([CH3:17])=[CH:15][C:14]([OH:18])=[CH:13][C:12]=1[CH3:19])=O)(C)(C)C.Cl>O1CCOCC1>[CH3:19][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[C:16]([CH3:17])[C:11]=1[CH2:10][C@@H:9]([C:20]([NH:22][C@@H:23]([C:25]([NH:27][CH2:28][C@H:29]([NH2:37])[CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:26])[CH3:24])=[O:21])[NH2:8]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 71229909N-(tert-Butoxycarbonyl)-2,6-dimethyl-L-tyrosyl-N-{(2R)-2-amino-3-phenylpropyl}-D-alaninamide

생성물 1

HCID 712299072,6-Dimethyl-L-tyrosyl-N-[(2R)-2-amino-3-phenylpropyl]-D-alaninamide수율 56%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

N-(tert-Butoxycarbonyl)-2,6-dimethyl-L-tyrosyl-N-{(2R)-2-amino-3-phenylpropyl}-D-alaninamide (203 mg, 0.36 mmol) was dissolved in 1 mL dioxane and hydrogen chloride (4M solution in dioxane, 1 mL, 4 mmol) added and the mixture stirred at room temperature for 16 h. The mixture was evaporated under reduced pressure and the residue purified by preparative HPLC and then freeze dried to provide the title compound (83 mg, 56%) as a white solid.

후처리

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue purified by preparative HPLC
  3. customfreeze dried

출처 및 근거

ORD 기록
ord-aa6ae07089374649a4b4dce49aee91cf
출처 데이터셋
uspto-grants-2015_02
특허 번호
US08957025B2

연결된 노트

불러오는 중…