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1-(3-Pyrrol-1-yl-phenyl)-ethylamine → HCID 86730225, 화합물

HRID 1850193
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HRID 1850193 반응식
Cl[C:2]1[N:7]=[C:6]([N:8]2[C@@H:12]([CH:13]([CH3:15])[CH3:14])[CH2:11][O:10][C:9]2=[O:16])[CH:5]=[CH:4][N:3]=1.[N:17]1([C:22]2[CH:23]=[C:24]([CH:28]([NH2:30])[CH3:29])[CH:25]=[CH:26][CH:27]=2)[CH:21]=[CH:20][CH:19]=[CH:18]1>CS(C)=O.CCOC(C)=O>[N:17]1([C:22]2[CH:23]=[C:24]([C@H:28]([NH:30][C:2]3[N:7]=[C:6]([N:8]4[C@@H:12]([CH:13]([CH3:15])[CH3:14])[CH2:11][O:10][C:9]4=[O:16])[CH:5]=[CH:4][N:3]=3)[CH3:29])[CH:25]=[CH:26][CH:27]=2)[CH:21]=[CH:20][CH:19]=[CH:18]1.[N:17]1([C:22]2[CH:23]=[C:24]([C@@H:28]([NH:30][C:2]3[N:7]=[C:6]([N:8]4[C@@H:12]([CH:13]([CH3:15])[CH3:14])[CH2:11][O:10][C:9]4=[O:16])[CH:5]=[CH:4][N:3]=3)[CH3:29])[CH:25]=[CH:26][CH:27]=2)[CH:21]=[CH:20][CH:19]=[CH:18]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 2

HCID 170247981-(3-Pyrrol-1-yl-phenyl)-ethylamineHCID 86730167(S)-3-(2-chloropyrimidin-4-yl)-4-isopropyloxazolidin-2-one

생성물 2

HCID 86730225HCID 86730225, 화합물HCID 86730226HCID 86730226, 화합물

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8857
Ethyl Acetate
용매

실험 절차

A solution of (S)-3-(2-chloropyrimidin-4-yl)-4-isopropyloxazolidin-2-one (86 mg, 0.36 mmol) and 1-(3-(1H-pyrrol-1-yl)phenyl)ethanamine (100 mg, 0.537 mmol, 1.5 equiv) in DMSO (1 mL) was heated at 110° C. for 1½ h. The reaction mixture was diluted with EtOAc (8 mL) and washed with water (30 mL). After separation, the aqueous phase was extracted with EtOAc (3×8 mL). Combined organics were dried over Na2SO4, filtered and concentrated. Silica gel column chromatography (EtOAc/Heptane 10 to 50%) provided (S)-3-(2-((R)-1-(3-(1H-pyrrol-1-yl)phenyl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one and (S)-3-(2-((S)-1-(3-(1H-pyrrol-1-yl)phenyl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one.

후처리

  1. washwashed with water (30 mL)
  2. customAfter separation
  3. extractionthe aqueous phase was extracted with EtOAc (3×8 mL)
  4. dry with materialCombined organics were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fcee83db950241c59fb9e630a37c3002
출처 데이터셋
uspto-grants-2015_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08957068B2

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